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Peer-reviewed veterinary case report

Aberrant resting-state functional connectivity in a genetic rat model of depression.

Journal:
Psychiatry research
Year:
2014
Authors:
Williams, Kathleen A et al.
Affiliation:
Department of Radiology · United States
Species:
rodent

Abstract

Abnormal intrinsic functional connectivity, measured by resting-state functional MRI, has been reported in major depressive disorder (MDD). Our study is the first to demonstrate hypo- and hyperconnectivity between the hippocampus and cortical, subcortical regions in a genetic animal model of depression, similar to connectivity anomalies found in MDD.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/24613017/