Peer-reviewed veterinary case report
Oral canine IFN-alpha4 reduces gum inflammation in dogs
By Ito, Akira et al.·Published in The Journal of veterinary medical science·2010·Research Institute of Genome-Based Biofactory, Japan·View original on PubMed →
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Original publication title: Ability of orally administered IFN-α4 to inhibit naturally occurring gingival inflammation in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with gum disease (gingival inflammation) was treated with a low dose of a special protein called canine interferon alpha-4 (CaIFN-α4) to see if it could help reduce their symptoms. After treatment, the dogs showed fewer harmful bacteria in their mouths and improvements in their gum health. Additionally, signs of stress in the dogs decreased. This suggests that giving CaIFN-α4 orally can be an effective way to help dogs with gum problems feel better.
People also search for: dog gum disease treatment · canine interferon for gingivitis · how to treat dog gingival inflammation
Abstract
It has been reported that type I interferons (IFN-α/β) play an important role in innate immune responses against viral and bacterial infections. In this study, we used and examined naturally occurred canine periodontal disease to show the therapeutic efficacy of low dose oral administration (LDOA) of canine IFN-α subtype 4 (CaIFN-α4). We administered purified recombinant CaIFN-α4 expressed in a baculovirus system to dogs with or without gingival inflammation. We found that LDOA of CaIFN-α4 reduce periodontopathic bacterial counts. LDOA induced improvement of naturally occurring gingival inflammation, and reduction of the stress marker responses was also observed after LDOA. These results suggest that LDOA of CaIFN-α4 has effectiveness for improvement of naturally occurring gingival inflammation in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20424396/