Peer-reviewed veterinary case report
Cat with high mast cells shows abnormal blood test scattergram
By Lavabre, Typhaine et al.·Published in Veterinary clinical pathology·2019·Equipe de Biologie Mé, France·View original on PubMed →
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Original publication title: Abnormal Sysmex XT-2000iV DIFF scattergram in a cat with a prominent mastocytemia.
- Species:
- cat
Plain-English summary
A 2-year-old neutered male domestic shorthair cat was taken to the emergency vet due to vomiting, diarrhea, lethargy, and not eating or drinking for two days. Blood tests showed unusual results, indicating a problem with the cat's white blood cells, specifically an abnormal presence of mast cells. Further testing confirmed that the unusual blood results were linked to a condition called systemic mastocytosis, where mast cells are present in higher numbers. The vet adjusted the testing method, and the results aligned with manual evaluations, helping to clarify the cat's condition. With proper diagnosis, the cat could receive appropriate treatment.
People also search for: cat vomiting and diarrhea · cat lethargy and inappetence · systemic mastocytosis in cats · abnormal blood test results in cats
Abstract
A 2-year-old neutered male domestic shorthair cat was presented to the emergency service of the National Veterinary School of Toulouse (France) for acute vomiting and diarrhea with lethargy, inappetence, and adypsia for the past 48 hours. Complete blood counts were performed with the ProCyte DX at the emergency department and with the Sysmex XT-2000iV at the laboratory 2 weeks later. The scattergrams from the two analyzers revealed similar unusual and abnormal dot plots. The Sysmex XT-2000iV DIFF scattergram also showed no clear separation between different leukocyte populations. The eosinophil cluster was in an abnormal location compared with that of the "typical" location in a normal cat. A blood smear evaluation revealed the presence of numerous mast cells. Thus, we hypothesized that the Sysmex XT-2000iV had detected the mast cell population, and this led to errors in the differential counts. To explore this hypothesis, we manually gated on the DIFF scattergram and performed a manual differential on the blood smear. With this new gating strategy, the Sysmex XT-2000iV and manual differentials were similar. Thus, in the case of systemic mastocytosis, mast cells can be located between the lymphocyte, monocyte, and eosinophil clusters on scattergrams.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31650566/