Peer-reviewed veterinary case report
Cyclosporine absorption in healthy cats after oral and skin treatment
By Miller, Rose et al.·Published in Journal of the American Animal Hospital Association·2014·College of Veterinary Medicine·View original on PubMed →
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Original publication title: Absorption of transdermal and oral cyclosporine in six healthy cats.
- Species:
- cat
Plain-English summary
A group of six healthy cats was given either oral cyclosporine or a skin cream version to see how well the medication worked for skin issues. The cats received the oral treatment for a week and the skin treatment for three weeks. The results showed that the oral cyclosporine reached much higher levels in the cats' blood compared to the skin cream, which only worked well in one cat. Because the skin treatment didn't consistently provide enough medication, it is not recommended for cats.
People also search for: cat skin problems treatment · cyclosporine for cats · transdermal medication for cats
Abstract
Cyclosporine is commonly used orally to treat feline dermatoses. Due to difficulties administering oral medications, veterinarians sometimes prescribe compounded transdermal cyclosporine, despite studies showing limited absorption. The study objective was to compare cyclosporine blood concentrations after oral administration to concentrations after transdermal application of cyclosporine (prepared in pluronic lecithin organogel [PLO]) in six cats using a controlled, cross-over design with a 2 wk washout period. Cats were dosed at 5.1-7.4 mg/kg of cyclosporine q 24 hr either per os for 7 days or transdermally for 21 days. Cyclosporine blood concentrations were measured q 7 days and after the washout period. A monoclonal-based immunoassay (lower limit of quantitation was 25 ng/mL) was used. Median concentrations on the seventh day were 2,208 ng/mL (range, 1,357-3,419 ng/mL) 2 hr after orally administered cyclosporine and 37 ng/mL (range, 25-290 ng/mL) 2 hr after transdermally applied cyclosporine. Median concentration on day 21 was 58 ng/mL (range, 51-878 ng/mL) 2 hr after transdermally applied cyclosporine. Concentrations were quantifiable for transdermally applied cyclosporine, but considered therapeutic in only one of six cats. Based on those results, transdermally applied cyclosporine was not recommended in cats because of inconsistent absorption.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24216498/