Peer-reviewed veterinary case report
Dog with rare jaw tumor showing mucinous gland growth
By Mineshige, Takayuki et al.·Published in The Journal of veterinary medical science·2025·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Acanthomatous ameloblastoma with mucinous glandular differentiation in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old male Chihuahua was brought in for a mass on the right side of his jaw. After a biopsy confirmed it was an acanthomatous ameloblastoma, a type of oral tumor, a CT scan showed that the tumor was affecting the bone. The dog underwent surgery to remove the mass, and further tests revealed unusual glandular features in the tumor, which had not been documented before. Fortunately, the tumor was found to be low-grade, suggesting a better prognosis, and the dog was treated successfully.
People also search for: Chihuahua jaw tumor · acanthomatous ameloblastoma treatment · dog oral tumor surgery
Abstract
This report describes an atypical case of canine acanthomatous ameloblastoma (CAA) with mucinous glandular differentiation in a 12-year-old male Chihuahua with a right mandibular mass. Initially diagnosed as CAA by biopsy, computed tomography revealed bone lysis, prompting surgical excision. Histological examination showed lobular growth with two distinct neoplastic cell populations: typical CAA-like cells and a minor glandular structure population. Mucinous glandular differentiation in CAA is undocumented in veterinary literature. Immunohistochemistry showed positivity for cytokeratin AE1/AE3 in all tumor cells, and cytokeratin CAM5.2 and Alcian blue staining confirmed glandular cells and mucin. A low mitotic and K-i67 proliferation index suggested low-grade malignancy. This rare case highlights the need for comprehensive histopathological and immunohistochemical analysis to distinguish CAA from other oral tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39756954/