Peer-reviewed veterinary case report
New fipronil and permethrin kills ticks on dogs
By Dumont, Pascal et al.·Published in Parasites & vectors·2015·Merial S.A.S., France·View original on PubMed →
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Original publication title: Acaricidal efficacy of a new combination of fipronil and permethrin against Ixodes ricinus and Rhipicephalus sanguineus ticks.
- Species:
- dog
Plain-English summary
A group of healthy adult dogs was treated with a new topical product containing fipronil and permethrin to see how well it worked against two types of ticks: Ixodes ricinus and Rhipicephalus sanguineus. After treatment, the dogs showed a remarkable 100% effectiveness in killing these ticks for at least four weeks. The product significantly reduced the number of live ticks compared to untreated dogs, making it a strong option for tick prevention. This means that using this combination treatment can help keep your dog tick-free for an extended period.
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Abstract
BACKGROUND: Two blinded, controlled laboratory studies were conducted to assess the acaricidal efficacy of a new combination of fipronil and permethrin (Frontline Tri-Act/Frontect) against two tick species. Study A evaluated the efficacy of the product against both Ixodes ricinus and Rhipicephalus sanguineus and Study B evaluated the efficacy against R. sanguineus only. METHODS: 16 (Study A) and 12 (Study B) healthy adult dogs were allocated to two groups in each study. Dogs in Group 1 served as untreated controls. Dogs in Group 2 were treated with a new topical spot-on formulation containing 6.76% (w/v) fipronil + 50.48% (w/v) permethrin once on Day 0. Each dog of study A was infested with 50 unfed adult ticks of each species and each dog of study B was infested with 50 unfed adult Rhipicephalus sanguineus prior to treatment (Day -2 in Study A, Day -1 in Study B) and post treatment on Days 7, 14, 21 and 28. The ticks were removed and counted 48 h after treatment (Day 2) or subsequent infestations (Days 9, 16, 23 and 30). Acaricidal efficacy was defined as the percent reduction in the number of live ticks in the treated group compared to the untreated control group. RESULTS: The percent efficacy in the treated group for R. sanguineus was 100%, 100%, 100%, 100% and 96.7% in Study A, and 94.4%, 100%, 100%, 98.7% and 98.0% in Study B, for counts performed on Days 2, 9, 16, 23 and 30, respectively. For I. ricinus, in Study A, the percent efficacy of the treatment was 100%, 100%, 100%, 100% and 99.2% for counts performed on Days 2, 9, 16, 23 and 30, respectively. There was a significant difference of the geometric mean numbers of live ticks between the treated and control groups at each time point in each study (p = 0.005 for every day in Study A, and p < 0.005 for every day in Study B). CONCLUSIONS: A single topical administration of a combination of fipronil and permethrin provides excellent acaricidal efficacy against both I. ricinus and R. sanguineus for at least 4 weeks.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25622698/