Peer-reviewed veterinary case report
Accelerated binding of autoantibody to red blood cells with increasing anaemia in cattle experimentally infected with Theileria sergenti.
- Journal:
- Journal of veterinary medicine. B, Infectious diseases and veterinary public health
- Year:
- 2004
- Authors:
- Shiono, H et al.
- Affiliation:
- National Institute of Animal Health · Japan
Abstract
Anaemia is the most important clinical manifestation in cattle infected with Theileria sergenti. In order to determine the mechanism of red blood cells (RBC) destruction in anaemic cattle, we studied the binding of autoantibody (IgG) to RBC during the development of anaemia in T. sergenti infection. The low levels of IgG-bound RBC before the development of anaemia were triggered in proportion with the progression of anaemia and parasitaemia. Our results suggest an accelerated destruction of RBC in anaemic cattle by IgG-dependent phagocytosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14995976/