Peer-reviewed veterinary case report
Autologous ruptured tissue speeds ACL tendon-bone healing in dogs
By Matsumoto, Tomoyuki et al.·Published in The American journal of sports medicine·2012·Department of Orthopaedic Surgery, Japan·View original on PubMed →
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Original publication title: Acceleration of tendon-bone healing of anterior cruciate ligament graft using autologous ruptured tissue.
- Species:
- dog
Plain-English summary
A group of beagle dogs underwent surgery to repair torn anterior cruciate ligaments (ACL) using their own tendon tissue. Half of the dogs received additional treatment with their own ruptured ACL tissue to help the healing process. Results showed that the dogs treated with the ruptured tissue had better integration of the tendon and bone, with stronger healing observed just four weeks after surgery. This suggests that using ruptured ACL tissue could improve recovery and strength in dogs undergoing ACL repair.
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Abstract
BACKGROUND: It has been recently reported that human anterior cruciate ligament (ACL) ruptured tissue contains abundant vascular stem cells that contribute to tendon-bone healing in an immunodeficient rat model of ACL reconstruction. HYPOTHESIS: Autologous ruptured ACL tissue has an effect on the maturation of bone-tendon integration in anterior cruciate ligament reconstruction. STUDY DESIGN: Controlled laboratory study. METHODS: Twenty healthy adult beagle dogs underwent bilateral ACL reconstruction using the ipsilateral flexor digitorum superficialis tendon and were divided into 2 groups: right knee (a tissue-treated group) and left knee (a control group). The tissue-treated group received autologous ruptured ACL tissue, which was obtained 2 days after resection and sutured to the tibial side of the graft. Histological, radiographic, and biomechanical assessments were performed. In addition, immunohistochemical staining was performed to assess angiogenesis and osteogenesis. RESULTS: Histological assessment and staining for osteoblasts and endothelial cells at week 2 demonstrated early healing, inducing endochondral ossification-like integration with enhanced angiogenesis and osteogenesis in the tissue-treated group's grafts. Computed tomography at week 4 showed a significantly smaller tibial bone tunnel in the tissue-treated group (tissue, 19.0 ± 4.4 mm(2); control, 42.6 ± 4.7 mm(2); P = .009, n = 5). Furthermore, biomechanical testing of force during loading to ultimate failure at week 4 demonstrated a significantly higher strength in the tissue-treated group (tissue, 66.4 ± 10.1 N; control, 30.5 ± 10.3 N; P = .009, n = 5). CONCLUSION: In the present study, the authors elucidated that transplantation of ACL-ruptured tissue, which was sutured to the tibial side of the graft, contributed to early tendon-bone healing in a canine model of ACL reconstruction. CLINICAL RELEVANCE: Anterior cruciate ligament ruptured tissue has a therapeutic potential in promoting an appropriate environment for tendon-to-bone healing in bone tunnels of ACL reconstruction.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22427618/