Peer-reviewed veterinary case report
Accuracy of quick blood crossmatch tests and risks in cats
By Blois, S L et al.·Published in Veterinary journal (London, England : 1997)·2021·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Accuracy of a point-of-care major crossmatch test and risk factors for major crossmatch incompatibility in cats.
- Species:
- cat
Plain-English summary
A study looked at how well a quick blood test for cats could match donors and recipients before a transfusion. The test, called GEL-CM, was compared to a more thorough lab test, and it turned out that the quick test didn't always agree with the lab results. Cats that had received blood before were more likely to have mismatches, which could lead to serious reactions. This means that if your cat has had a transfusion in the past, it's especially important to do a proper crossmatch to avoid complications.
People also search for: cat blood transfusion risks · why is my cat getting a blood transfusion · cat blood donor compatibility test
Abstract
Major crossmatch testing can help identify immunologic incompatibilities between blood donors and recipients; however, there are limited studies describing the accuracy of point-of-care crossmatch tests. The first aim of this study was to determine if a gel-based, point-of-care major crossmatch method (GEL-CM), without antiglobulin-enhancement, could accurately detect compatible and incompatible donor-recipient pairings, using an antiglobulin-enhanced laboratory-based major crossmatch method (LAB-CM) as the reference standard. The second aim was to describe the incidence of, and risk factors for, major crossmatch incompatibility in cats. Nineteen previously-transfused cats and 32 transfusion-naïve cats, representing 132 unique donor-recipient pairings, were included in this study. Both LAB-CM and GEL-CM tests were performed for most parings. There was poor agreement between the LAB-CM and GEL-CM results (kappa = 0.111; 95% confidence interval [CI], -0.093 to 0.314). Transfusion-naïve cats had incompatibility rates of 3% and 6% using LAB-CM and GEL-CM, respectively; previously-transfused cats had incompatibility rates of 32% and 26% using LAB-CM and GEL-CM, respectively. History of previous transfusion was the only identified cat risk factor for an incompatible LAB-CM (odds ratio [OR], 31.0; 95% CI, 3.77-254.98; P = 0.0019) and GEL-CM (OR, 5.7; 95% CI, 1.72-19.20; P = 0.0054). Further studies are needed to determine if GEL-CM can detect clinically-relevant immunologic incompatibilities that would result in transfusion reactions. Major crossmatch testing is of greater importance in cats that have previously received a transfusion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33941337/