Peer-reviewed veterinary case report
Acetylcholine receptor antibody-mediated animal models of myasthenia gravis and the role of complement.
- Journal:
- Annals of the New York Academy of Sciences
- Year:
- 2018
- Authors:
- Kusner, Linda L et al.
- Affiliation:
- Department of Pharmacology and Physiology · United States
Abstract
Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessment for potential MG treatments. Here, we provide a focused summary of these recommendations and the role of complement in disease development in experimental models of MG.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29356015/