Peer-reviewed veterinary case report
Heart failure after low adrenal hormone treatment in two dogs
By Jett, Lindsey et al.·Published in Journal of the American Animal Hospital Association·2022·From Pittsburgh Veterinary Specialty and Emergency Center, United States·View original on PubMed →
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Original publication title: Acquired Systolic Dysfunction and Subsequent Congestive Heart Failure Following Treatment of Hypoadrenocorticism in Two Dogs.
- Species:
- dog
Plain-English summary
A 5-year-old male Labrador and a 7-year-old female mixed breed were brought to the vet because they were weak and sometimes collapsed. After tests, both dogs were diagnosed with hypoadrenocorticism (a condition where the adrenal glands don't produce enough hormones). They were treated with medications, but unfortunately, both developed heart problems, specifically congestive heart failure, and were later euthanized due to their poor condition and low quality of life. This highlights the potential heart issues that can arise in dogs with this hormonal imbalance.
People also search for: dog weakness collapse · hypoadrenocorticism treatment in dogs · congestive heart failure in dogs
Abstract
Acquired cardiomyopathies have been described in human patients with hypoadrenocorticism. Several mechanisms have been described to explain the cardiac effects of primary adrenal insufficiency, but, clinically, these manifestations may be underappreciated in dogs. In humans, there is an infrequently described, reversible dilated cardiomyopathy in patients with hypoadrenocorticism. Two dogs were presented to a single referral center for evaluation of weakness or collapse and were subsequently diagnosed with hypoadrenocorticism after a full diagnostic workup. Following the diagnosis of hypoadrenocorticism and administration of glucocorticoids and desoxycorticosterone pivalate, both dogs developed left-sided congestive heart failure and had systolic dysfunction diagnosed by echocardiogram. Both dogs were euthanized; one because of recurrent congestive heart failure and another because of a concern for poor long-term prognosis and decreased quality of life. The purpose of this case report is to document multiple cases of hypoadrenocorticism-associated systolic dysfunction and subsequent cardiogenic pulmonary edema in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36315864/