Peer-reviewed veterinary case report
Fungal eye infection Acremonium in a cat treated with voriconazole
By Binder, Daniel R et al.·Published in Veterinary ophthalmology·2011·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Acremonium keratomycosis in a cat.
- Species:
- cat
Plain-English summary
A 14-year-old female Domestic Short-haired cat was brought in for worsening eye problems, including a painful corneal ulcer, watery discharge, and squinting. After tests showed a fungal infection caused by Acremonium, the cat was initially treated with one antifungal medication but didn't improve. The vet then switched to a different antifungal, voriconazole, which successfully cleared the infection and helped the cat's eye heal.
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Abstract
A 14-year-old, female spayed Domestic Short-haired cat was presented for evaluation of progressive superficial corneal ulceration with mucoid ocular discharge, blepharospasm, and conjunctival hyperemia OD. Upon examination, ulcerative keratitis with stromal loss, chemosis, corneal edema, miosis, aqueous flare, and hyphema were noted. Corneal cytology revealed branching, septate fungal hyphae with bulbous terminations and associated ovoid structures, with suppurative inflammation. Fungal culture of corneal swabs confirmed the presence of Acremonium, although PCR of the cytology sample was negative. Ten days of treatment with topical 1% miconazole resulted in clinical deterioration before switching to topical 1% voriconazole solution, which was successful in resolving the infection. The apparent clinical efficacy of the topical antifungals used contrasted with the in vitro susceptibility profile.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21923833/