Peer-reviewed veterinary case report
Acrolein: An Effective Biomarker for Tissue Damage Produced from Polyamines.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2018
- Authors:
- Igarashi, Kazuei et al.
- Affiliation:
- Amine Pharma Research Institute · Japan
Abstract
It is thought that the major factor responsible for cell damage is reactive oxygen species (ROS), but our recent studies have shown that acrolein (CH=CH-CHO) produced from spermine and spermidine is more toxic than ROS. Thus, (1) the mechanism of acrolein production during brain stroke, (2) one of the mechanisms of acrolein toxicity, and (3) the role of glutathione in acrolein detoxification are described in this chapter.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29080188/