Peer-reviewed veterinary case report
Activation of maternal toll-like receptor-2 causes social deficits and memory impairment in female offspring.
- Journal:
- Neuroreport
- Year:
- 2016
- Authors:
- Lee, Younghwa et al.
- Affiliation:
- Departments of aLife and Nanopharmaceutical Sciences bOriental Pharmaceutical Science cKyung Hee East-West Pharmaceutical Research Institute · South Korea
Abstract
To study the relevance of the activation of toll-like receptor-2 and abnormal behavioral properties, we introduced prenatal zymosan, a toll-like receptor-2 ligand, to investigate the effect of maternal immunity on offspring behavior. Only female offspring showed impaired social and cognitive function, suggesting that zymosan may influence females' behavior.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26765791/