Peer-reviewed veterinary case report
Immune response in cats triggered by nasal immune stimulant delivery
By Wheat, William et al.·Published in Journal of veterinary internal medicine·2019·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Activation of upper respiratory tract mucosal innate immune responses in cats by liposomal toll-like receptor ligand complexes delivered topically.
- Species:
- cat
Plain-English summary
Seven healthy cats were tested with a new immune booster that was applied to their noses and throats to see if it could help protect them from respiratory infections. The treatment quickly activated their immune systems, leading to a stronger response against potential viruses and bacteria. This suggests that this new liposome-toll-like receptor complex could be a promising option for keeping cats healthier and preventing upper respiratory issues.
People also search for: cat respiratory infection prevention · immune booster for cats · how to protect cats from colds
Abstract
BACKGROUND: Nonspecific induction of local innate immune responses by mucosally administered immunotherapy is a new approach to protection from upper respiratory tract infections. Therefore, a new liposome-toll-like receptor complex (LTC) immune stimulant was developed and investigated for its ability to activate innate immune responses in cats, both in vitro and in vivo, as part of an initial evaluation of LTC for use as an immunotherapeutic agent in cats. OBJECTIVES: We hypothesized that LTC could activate innate immune responses in cats after topical application to nasal and oropharyngeal mucosal surfaces. ANIMALS: Mucosal immune responses to topical administration of LTC were assessed in 7 healthy, purpose-bred cats, and in vitro responses were assessed using blood samples from healthy cats. METHODS: Cytokine and cellular immune responses to LTC were evaluated in blood samples, nasal lavage specimens, and pharyngeal swabs from cats, using reverse transcriptase polymerase chain reaction assays, ELISA assays, and flow cytometry. RESULTS: Liposome-TLR complexes rapidly activated leukocytes in vitro, including upregulation of costimulatory molecule expression and cytokine production. Topical administration of LTC in healthy cats triggered rapid recruitment of monocytes to the nasal and oropharyngeal mucosa. CONCLUSIONS AND CLINICAL IMPORTANCE: Liposome-TLR complexes were found to effectively activate innate immune responses in cats after mucosal administration. These findings suggest that LTC have potential for use as a new mucosally administered immunotherapy for nonspecific protection from viral and bacterial respiratory tract infections.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30770582/