Peer-reviewed veterinary case report
Active expression of matrix metalloproteinase-13 mRNA in the granulation tissue of equine superficial digital flexor tendinitis.
- Journal:
- The Journal of veterinary medical science
- Year:
- 2007
- Authors:
- Nomura, Masayuki et al.
- Affiliation:
- School of Veterinary Medicine · Japan
- Species:
- horse
Abstract
The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon. In situ hybridization also revealed that fibroblastic cells proliferated in the granulation tissue generated in the tendinitis actively expressed MMP-13 mRNA. On the other hand, in normal tendon, a few fibroblastic cells and vascular components lied in the endotenon barely expressed its mRNA, but other cellular components in the tendon bundle were not positively hybridized. As mentioned above, MMP-13 but not other collagenases or gelatinases, may play an important role in tendon injuries in the racehorses.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17611361/