Peer-reviewed veterinary case report
Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2009
- Authors:
- Nikonenko, Boris V et al.
- Affiliation:
- Sequella · United States
Abstract
New delivery vehicles and routes of delivery were developed for the capuramycin analogue SQ641. While this compound has remarkable in vitro potency against Mycobacterium tuberculosis, it has low solubility in water and poor intracellular activity. We demonstrate here that SQ641 dissolved in the water-soluble vitamin E analogue alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) or incorporated into TPGS-micelles has significant activity in a mouse model of tuberculosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19414567/