Peer-reviewed veterinary case report
Activity of thyroid parafollicular (C) cells in rats with hyperthyroidism--immunohistochemical investigations.
- Journal:
- Roczniki Akademii Medycznej w Bialymstoku (1995)
- Year:
- 2004
- Authors:
- Dadan, J et al.
- Affiliation:
- 1st Department of General and Endocrinological Surgery
- Species:
- rodent
Abstract
The aim of this study was an evaluation of the activity of parafollicular (C) cells in a rat experimental model of hyperthyroidism, evoked by an intraperitoneal application of L-thyroxine (40 mg/kg daily) over 15 days. For that reason, immunohistochemical investigations and evaluation of calcitonin (CT) plasma concentrations were performed. Differences in the quantity and distribution, together with enhanced CT-immunoreactivity of C cells, were observed in hyperthyroid rats, in comparison to respective values in the control group, accompanied by a significant diminution of plasma TSH and CT levels. Our preliminary study may point to a functional interaction between follicular and parafollicular cells in the thyroid gland.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15638399/