Peer-reviewed veterinary case report
Heart failure dogs show better heart timing with new pacing method
By Qiu, Qiong et al.·Published in Journal of cardiac failure·2017·Department of Cardiology, China·View original on PubMed →
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Original publication title: Acute Effects of Multisite Biventricular Pacing on Dyssynchrony and Hemodynamics in Canines With Heart Failure.
- Species:
- dog
Plain-English summary
A group of dogs with heart failure underwent a new treatment called multisite biventricular pacing (MSP) to see if it could help their heart function better compared to the standard biventricular pacing (BVP). After three weeks of rapid pacing, the dogs showed improvements in heart rhythm and pressure measurements with MSP, indicating better synchronization of heartbeats. The results suggested that MSP could be a more effective option for managing heart failure in dogs, leading to better overall heart function.
People also search for: dog heart failure treatment · multisite biventricular pacing for dogs · improving dog heart function
Abstract
BACKGROUND: Multisite biventricular pacing (MSP) has been proposed as an alternative strategy to improve the efficiency of conventional biventricular pacing (BVP), but its utility remains unclear. This study sought to investigate whether MSP induced better synchrony and hemodynamic effects in canines with heart failure. METHODS AND RESULTS: After 3 weeks' rapid right ventricular pacing, 7 canines were sutured with 4 left ventricular (LV) leads on the anterior, lateral, posterior, and apical walls and followed by MSP and BVP. Hemodynamic, electrocardiographic, and echocardiographic parameters were measured. Dyssynchrony was assessed by tissue Doppler imaging for Yu-index (longitudinal direction) and speckle tracking imaging for the standard deviation of time to peak radial strains (SD, radial direction). Compared with BVP, mean MSP reduced QRS width (P < .05), Yu-index (25.3 ± 1.9 ms vs 31.6 ± 4.3 ms, P = .008), SD(32.8 ± 5.9 ms vs 37.3 ± 7.9 ms, P = .032), and LV end-diastolic pressure (P < .05). The optimal pacing site combination improved QRS width, Yu-index, SD, LV end-diastolic pressure, and the maximum derivative of LV pressure (dP/dt) significantly (all P < .05), but the worst MSP (with the smallest dP/dt) did not show any improvement to BVP. CONCLUSIONS: MSP is superior to BVP in reducing dyssynchrony and improving hemodynamics. The pacing site combination has a potential effect on MSP response.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28126497/