Peer-reviewed veterinary case report
Brain tumor swelling and symptoms improve in dogs
By Rossmeisl, John H & Garcia-Mora, Josefa K·Published in Journal of veterinary internal medicine·2025·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Acute Evolution of Neurological Signs and Magnetic Resonance Imaging Features in Dogs With Brain Tumors Receiving Treatment With Corticosteroids and Anticonvulsants.
- Species:
- dog
Plain-English summary
A group of dogs with brain tumors, including gliomas and meningiomas, were treated with corticosteroids and anticonvulsants to manage their neurological symptoms. After treatment, about half of the dogs showed improvement in their symptoms and quality of life, with many also experiencing a reduction in brain swelling as seen on MRI scans. The study found that dogs who responded well to treatment had more significant decreases in swelling and tumor size compared to those who did not respond. Overall, corticosteroids appeared to help many dogs with brain tumors feel better and improve their condition.
People also search for: dog brain tumor treatment · corticosteroids for dogs with tumors · dog neurological signs improvement
Abstract
BACKGROUND: Corticosteroids (CS) are a common treatment prescribed for dogs with brain tumors, but little data characterizing the clinical and neuroradiologic effects of CS treatment exist. HYPOTHESES: Decreases in peritumoral brain edema (PBE) would be observed in dogs with brain tumors treated with CS and anticonvulsants, and decreases in edema would be accompanied by clinical improvement. ANIMALS: Fifty dogs with gliomas and 22 with meningiomas. MATERIALS AND METHODS: Retrospective case series. Dogs with brain tumors receiving treatments with CS and anticonvulsants underwent pre- and posttreatment clinical and brain magnetic resonance imaging (MRI) examinations within a 3-week follow-up period, and peritumoral edema and tumor volumes were calculated from each MRI study. Dogs were characterized as clinical responders or nonresponders independent of imaging results based on longitudinal changes in clinical findings and owner-reported quality of life (QOL). Clinicopathologic and MRI variables were compared pre- and posttreatment by clinical response. RESULTS: At follow-up, 23/50 (46%) of dogs with glioma and 15/22 (68%) with meningioma were classified as clinical responders, and 23/50 (46%) of gliomas and 14/22 (64%) of meningiomas had decreases in edema volume. Responders had significantly larger decreases in edema and mass effect than nonresponders. Decreases in tumor volumes occurred in approximately 25% of gliomas. CONCLUSIONS AND CLINICAL IMPORTANCE: Peritumoral brain edema was decreased in 50%-60% of gliomas and meningiomas in dogs at follow-up, and amelioration of edema often was accompanied by improved neurological signs and QOL. Corticosteroids may also clinically benefit dogs without PBE and can influence MRI surrogates used to determine glioma therapeutic responses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40387432/