Peer-reviewed veterinary case report
Acute morphine exposure potentiates the development of HSV-1-induced encephalitis.
- Journal:
- Journal of neuroimmunology
- Year:
- 2006
- Authors:
- Lioy, Daniel T et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- rodent
Abstract
A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the disease remain to be elucidated. The current study examined the effects of a single dose of morphine prior to infection with HSV-1 on the development of HSVE in BALB/cByJ mice. Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16325924/