Peer-reviewed veterinary case report
Acute pancreatitis and acute kidney injury in dogs.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2019
- Authors:
- Gori, E et al.
- Affiliation:
- Veterinary Teaching Hospital 'Mario Modenato' · Italy
- Species:
- dog
Plain-English summary
This study looked at dogs with acute pancreatitis, which is a sudden inflammation of the pancreas, and how often they also developed acute kidney injury, a serious condition where the kidneys suddenly stop working well. The researchers found that out of 65 dogs with acute pancreatitis, about 26% also had acute kidney injury, and those dogs had a much higher chance of not surviving. They discovered that dogs with higher clinical severity scores and certain blood test results, like higher levels of urea and creatinine, were more likely to have a poor outcome. Overall, the findings suggest that having acute kidney injury along with acute pancreatitis is linked to a worse prognosis for dogs.
Abstract
Acute pancreatitis and acute kidney injury are well-documented comorbidities in human medicine. Dogs that develop acute kidney injury during hospitalization have significantly higher mortality rates than those that do not. The aim of this study was to evaluate the prevalence of acute kidney injury in dogs with acute pancreatitis and the prognostic value of various clinicopathological parameters. Cases of acute pancreatitis presented between January 2012 and June 2016 were identified. The diagnosis of acute pancreatitis was based on two or more of the following clinical signs: abdominal pain, diarrhea, vomiting or anorexia/hyporexia, no other abdominal extra-pancreatic diseases at abdominal ultrasound, and abnormal SNAP cPL test. Diagnosis of acute kidney injury was based on the guidelines of the International Renal Interest Society. Dogs were classified into survivors and non-survivors. Serum creatinine, urea, amylase, total calcium, total cholesterol, C-reactive protein, WBC and band neutrophils were evaluated at admission. Clinical severity index was calculated at admission. Clinical and clinicopathological data were compared between survivors and non-survivors. Sixty-five dogs with acute pancreatitis were assessed. Clinical severity index≥6.5 were associated with poor outcome (P=0.0011). Serum urea and creatinine concentrations at admission were significantly lower in survivors than non-survivors (P<0.0001 and P=0.0002, respectively). Acute kidney injury was diagnosed in 17/65 dogs (26.2%) and was associated with poor outcome (P<0.0001). Oligo-anuria was associated with poor outcome (P=0.0294). Increased clinical severity index and azotemia in dogs with acute pancreatitis were associated with an increased risk of mortality. Acute kidney injury may be a comorbidity of canine acute pancreatitis. The presence of oligo-anuria is associated with poor outcome.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30819430/