Peer-reviewed veterinary case report
Acute phase proteins and lipoprotein changes in dogs with systemic
By Behling-Kelly, Erica et al.·Published in Journal of veterinary internal medicine·2022·Department of Population Medicine and Diagnostic Sciences, United States·View original on PubMed →
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Original publication title: Acute phase protein response and changes in lipoprotein particle size in dogs with systemic inflammatory response syndrome.
- Species:
- dog
Plain-English summary
A group of dogs with severe infections (sepsis) and those with other types of inflammation were tested to see how certain proteins in their blood could help identify their condition. The study found that dogs with sepsis had much higher levels of serum amyloid A (SAA) and C-reactive protein (CRP) compared to healthy dogs. This information could help veterinarians determine whether a dog is suffering from a serious infection or a different type of inflammation. The researchers suggest that measuring these proteins could improve diagnosis and treatment for affected dogs.
People also search for: dog sepsis symptoms · high SAA levels in dogs · dog inflammation treatment
Abstract
BACKGROUND: Improved methodology to measure acute phase proteins and determination of lipoprotein particle-size distribution (PSD) could be clinically useful in dogs with systemic inflammatory processes. OBJECTIVES: Evaluate an immunoturbidometric assay for serum amyloid A (SAA) and lipoprotein PSD in dogs with sepsis, nonseptic systemic inflammation, and in healthy controls. Correlate dyslipidemic changes with SAA and C-reactive protein (CRP) concentrations. ANIMALS: Twenty-five dogs with sepsis, 15 dogs with nonseptic systemic inflammation, and 22 healthy controls. METHODS: Prospective, case-control study. Variables included SAA, CRP, and electrophoretic subfractionation of high- and low-density lipoproteins (HDL, LDL). Continuous variables were compared using ANOVA or Kruskal-Wallis tests with linear regression or Spearman's rank correlation used to assess relationships between variables. RESULTS: Median SAA and CRP concentrations were greater in dogs with sepsis (SAA 460 mg/L, interquartile range [IQR] 886 mg/L; CRP 133.2 mg/L, IQR 91.6 mg/L) and nonseptic inflammation (SAA 201 mg/L, IQR 436 mg/L; CRP 91.1 mg/L, IQR 88.6 mg/L) compared to healthy dogs (SAA 0.0 mg/L, IQR 0.0 mg/L; CRP 4.9 mg/L, IQR 0.0 mg/L) P < .0001. A cutoff of >677.5 mg/L SAA was 43.2% sensitive and 92.3% specific for sepsis. Low-density lipoprotein was higher in dogs with sepsis 29.6%, (mean, SD 14.6) compared to 14.4% (mean, SD 5.6) of all lipoproteins in healthy controls (P = .005). High-density lipoprotein was not associated with CRP but was negatively correlated with SAA (r-0.47, P < .0001). Subfractions of LDL and HDL differed between groups (all P < .05). CONCLUSIONS AND CLINICAL IMPORTANCE: Measurement of SAA using the immunoturbidometric assay evaluated in this study and lipoprotein PSD in dogs with inflammation might help distinguish septic from nonseptic causes of inflammation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35420224/