Peer-reviewed veterinary case report
Acute kidney failure in cats after oral paromomycin treatment
By Gookin, J L et al.·Published in Journal of the American Veterinary Medical Association·1999·Department of Anatomy, United States·View original on PubMed →
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Original publication title: Acute renal failure in four cats treated with paromomycin.
- Species:
- cat
Plain-English summary
Four cats developed acute kidney failure after being given an antibiotic called paromomycin to treat an intestinal infection. Thankfully, all four cats responded well to fluid therapy and their kidney function improved. However, three of the cats later experienced hearing loss and cataracts as side effects. This situation highlights the risks of using high doses of paromomycin, especially in cats with damaged intestines.
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Abstract
Acute renal failure was diagnosed in 4 cats receiving paromomycin orally for treatment of infectious enteritis. All 4 cats responded to fluid therapy and recovered normal or near-normal renal function; however, 3 of the cats subsequently became deaf and developed cataracts. Toxicoses were attributed to a combination of an excessive dosage of paromomycin and absorption of the drug across injured intestinal mucosal epithelium. Pharmacokinetic studies are needed to further define the disposition of paromomycin after oral administration to cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10613215/