Peer-reviewed veterinary case report
Acute spinal cord injury diminishes silent synapses in the rat hippocampus.
- Journal:
- Neuroreport
- Year:
- 2017
- Authors:
- Jing, Yingli et al.
- Affiliation:
- aRehabilitation Medicine of Capital Medical University bChina Rehabilitation Research Center and Beijing Bo Ai Hospital cInstitute of Rehabilitation Science of China dCenter of Neural Injury and Repair · China
- Species:
- rodent
Abstract
Spinal cord injury (SCI) can promote profound functional modification in various brain centers. However, the question of whether SCI can affect the generation of silent synapses that regulate neuronal plasticity in the hippocampus remains unclear. In the present studies, we demonstrated that acute SCI diminished silent synapses in hippocampus of lesioned rats. Furthermore, the SCI induced decline in silent synapses appeared to require the activation of NR2B-containing N-methyl-D-aspartate receptors. Our data show that SCI impaired synaptic plasticity in the hippocampus, suggesting that this region may serve as a potential therapeutic target for meliorating impaired brain functions after SCI.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29076975/