Peer-reviewed veterinary case report
Three dogs developed bloody bladder inflammation after one
By Peterson, J L et al.·Published in Journal of the American Veterinary Medical Association·1992·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Acute sterile hemorrhagic cystitis after a single intravenous administration of cyclophosphamide in three dogs.
- Species:
- dog
Plain-English summary
Three dogs developed blood in their urine, frequent urination, and difficulty urinating after receiving cyclophosphamide, a chemotherapy drug. An 11-year-old mixed-breed dog, a 4-year-old Gordon Setter, and a 6-year-old German Shepherd were all treated for different types of cancer when they experienced these symptoms within a day of their first dose. Tests showed that the dogs had sterile hemorrhagic cystitis, meaning their bladder was inflamed and bleeding, but there were no infections present. This case highlights the need for careful monitoring after administering cyclophosphamide, even if it’s given in standard doses.
People also search for: dog blood in urine after chemotherapy · cyclophosphamide side effects in dogs · dog frequent urination treatment
Abstract
Three dogs receiving cyclophosphamide IV as part of a combination chemotherapeutic regimen developed macrohematuria, stranguria, and pollakiuria within 24 hours of administration of the first dose of this drug. An 11-year-old spayed mixed-breed dog with an oral squamous cell carcinoma was administered 250 mg of cyclophosphamide/m2 of body surface, whereas a 4-year-old castrated male Gordon Setter was treated with 100 mg of cyclophosphamide/m2 and a 6-year-old male German Shepherd Dog with a cutaneous hemangiosarcoma was administered 140 mg of cyclophosphamide/m2. Aerobic bacterial culture, antimicrobial susceptibility testing, and urinalysis were performed on urine obtained by cystocentesis from all 3 dogs after hematuria was observed. Sterile hemorrhagic cystitis was diagnosed on the basis of large numbers of RBC in the urine, lack of pathogens on bacterial culturing of urine, and clinical signs. Although cyclophosphamide-induced cystitis in dogs has been reported in the literature numerous times, acute episodes developing within 24 hours of administration of the first dose have not been reported in this species with the use of therapeutic doses. Therefore, appropriate precautionary steps should be taken, even when the drug is being administered intermittently.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/1289337/