Peer-reviewed veterinary case report
ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model.
- Journal:
- Journal of negative results in biomedicine
- Year:
- 2016
- Authors:
- Liu, Min et al.
- Affiliation:
- Key Laboratory of Brain Functional Genomics (East China Normal University) · China
- Species:
- rodent
Abstract
BACKGROUND: In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene. RESULTS: We successfully constructed Adamts-18 knockout mice with BALB / c background. RT-PCR analysis showed syngeneic mammary tumor cell line 4 T1 per se has weakly endogenous ADAMTS-18 expression. Orthotopic inoculation of 4 T1 cells within the mammary fat pad of host mice, we found no significant difference in tumor growth and metastasis between Adamts-18 knockout mice and widetype control. CONCLUSIONS: We did not confirm that ADAMTS-18 in the host tissues is relevant for breast tumor progress in a murine 4 T1 breast cancer model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26841794/