Peer-reviewed veterinary case report
Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells.
- Journal:
- Biotechnology letters
- Year:
- 2013
- Authors:
- Du, Jun et al.
- Affiliation:
- Institute of Biotechnology · China
- Species:
- rodent
Abstract
BmK CT, one of the key toxins in the venom of the scorpion, Buthus martensii Karsch, can interact specifically with glioma cells as a chloride channel blocker and inhibit the invasion and migration of those cells via MMP-2. A recombinant adenovirus, Ad-BmK CT, was constructed and characterized by in vitro and in vivo studies, using MTT cytotoxicity assay and the glioma C6/RFP (red fluorescence protein)/BALB/c allogeneic athymic nude mice model, respectively. The adenovirus-mediated expression of BmK CT displayed a high activity in suppressing rat C6 glioma cells growth and invasion thereby suggesting that this recombinant adenovirus may be a powerful method for treating glioblastoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23443213/