Peer-reviewed veterinary case report
Adenoviruses isolated from wild gorillas are closely related to human species C viruses.
- Journal:
- Virology
- Year:
- 2013
- Authors:
- Duncan, McVey et al.
- Affiliation:
- GenVec · United States
Abstract
We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23806387/