Peer-reviewed veterinary case report
Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy.
- Journal:
- FEBS letters
- Year:
- 2017
- Authors:
- Li, Xue et al.
- Affiliation:
- Okinawa Institute of Science and Technology Graduate University · Japan
- Species:
- rodent
Abstract
Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Ppargmice; thus, Cnot3mice exhibit lipodystrophy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28032897/