Peer-reviewed veterinary case report
Chemotherapy with CCNU and prednisone for dogs after partial mast
By Hosoya, Kenji et al.·Published in Journal of the American Animal Hospital Association·2009·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors.
- Species:
- dog
Plain-English summary
Twelve dogs with grade 2 mast cell tumors (MCTs) that were not completely removed during surgery were treated with a combination of chemotherapy drugs, CCNU (lomustine) and prednisone. None of the dogs experienced local recurrence or spread of the cancer, which is a positive outcome. However, two dogs did suffer from serious liver failure. For the dogs that survived, 100% were free from progression of the disease after one year, and 77% remained progression-free after two years. This treatment option may be a good alternative to radiation therapy for dogs with incompletely excised MCTs.
People also search for: dog mast cell tumor treatment · CCNU for dogs · prednisone side effects in dogs
Abstract
The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19122059/