Vetmedin treatment effects in small dogs with chronic heart failure

Abstract

In the study, the influence of the drug "Vetmedin" on the heart condition of the dogs of small breeds, suffering from chronic cordiac insufficiency, was studied. In the control group of animals , the average thick-ness of the interventricular septum in the diastole stage (MLPd, mm) was 3.36 ± 0.44 mm, and in the test group 3.41 ± 0.38 mm. The average value of the thickness of the ventricular septum in the systole stage (MLPS, mm) was 4.36 ± 0.52 mm in the control and 4.33 ± 0.39 mm in the test group. The thickness of the posterior wall of the left ventricle in the diastole stage (CDFd, mm) in healthy dogs was 3.66 ± 0.47 mm, and in the test group - 3.58 ± 0.37 mm. The thickness of the posterior wall of the left ventricle at the systole stage (LFRA, mm) was 5.34 ± 0.40 mm and 5.48 ± 0.33 mm, respectively. The results were lower than the minimum acceptable physiological values for dogs and showed excessive tension of heart chambers in sick animals. It was found that oral ad-ministration of "Vetmedin" twice a day, at a daily dosage of 0.5 mg /kg of body weight for 30 days, contributed to the improvement of the general condition of animals, increase of their physical activity and decrease of blood pressure at the average on the 26.9% and brought it closer to physiological values. Ultrasound diagnosis of the heart allowed to conclude that this drug contributes to im-provement of heart muscle in dogs and leads to normalization of its wall thickness already on the 30th day of administration.