Peer-reviewed veterinary case report
ACTH hormone raises cortisol but not parathyroid hormone in dogs
By Kilpatrick, Scott et al.·Published in Research in veterinary science·2015·Royal (Dick) School of Veterinary Studies, United Kingdom·View original on PubMed →
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Original publication title: Adrenocorticotrophic hormone causes an increase in cortisol, but not parathyroid hormone, in dogs.
- Species:
- dog
Plain-English summary
A group of dogs was tested to see how a hormone called adrenocorticotrophic hormone (ACTH) affects cortisol and parathyroid hormone levels. After receiving ACTH, the dogs showed a significant increase in cortisol but no change in parathyroid hormone levels. This suggests that while cortisol levels can rise with ACTH treatment, they do not immediately affect calcium balance in a way that would trigger an increase in parathyroid hormone. The findings help clarify how these hormones interact in dogs with certain health issues.
People also search for: dog cortisol levels · dog calcium balance · ACTH hormone effects in dogs
Abstract
Dogs with spontaneous disorders of glucocorticoid production often have marked disturbances in calcium homeostasis. For example, hypercalcaemia is frequently observed in dogs with hypoadrenocorticism and secondary hyperparathyroidism is a common feature of canine hyperadrenocorticism. The mechanism(s) by which glucocorticoids modulate calcium homeostasis in dogs remains ill-defined. The hypothesis of this study is that a marked increase in serum cortisol concentrations would lead to an immediate negative calcium balance state which would drive a compensatory increase in parathyroid hormone (PTH) concentrations. This hypothesis was investigated by measuring serum cortisol and plasma PTH concentration in 19 dogs before and after administration of adrenocorticotrophic (ACTH) hormone. Post ACTH administration, there was a significant increase in serum cortisol, but not PTH, concentrations. The results of this study do not support the hypothesis that an increase in endogenous glucocorticoids influences calcium balance sufficiently to cause an immediate, compensatory increase in parathyroid hormone concentration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25544698/