Advances in the understanding of the clinically relevant genetic pathways and molecular aspects of canine mammary tumours: part 1. Proliferation, apoptosis and DNA repair.

Abstract

There have been significant recent advances in the understanding of the molecular events and critical pathways associated with and driving cancer of the mammary gland in humans and dogs. The study of canine mammary tumour biology, particularly of the molecular events associated with proliferation, cell survival, invasion and metastasis, is crucial for the development of effective therapeutic agents and strategies. In this first part of a two-part review, recent advances in the understanding of the clinically relevant genetic and molecular pathways driving cell proliferation, apoptosis and DNA repair in canine mammary gland tumours are described.