Peer-reviewed veterinary case report
Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos.
- Journal:
- Journal of nanobiotechnology
- Year:
- 2024
- Authors:
- Zhou, Renyi et al.
- Affiliation:
- Department of Orthopedics · China
- Species:
- rodent
Abstract
This study investigated the mechanism of the extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was synthesized and evaluated for its impact on chondrocyte viability and neutrophil extracellular traps (NETs) formation. In an OA rat model, GMOCS-Exos promoted cartilage regeneration and inhibited NETs formation. Transcriptome sequencing identified TGFB1 as a key gene, with GMOCS-Exos activating Nrf2 signaling through TGFB1. Depletion of TGFB1 hindered the cartilage-protective effect of GMOCS-Exos. This study sheds light on a promising therapeutic strategy for osteoarthritis through GMOCS-Exos-mediated TGFB1/Nrf2 pathway modulation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39160590/