Peer-reviewed veterinary case report
Vaccine side effects in dogs within 3 days of shots
By Moore, George E et al.·Published in Journal of the American Veterinary Medical Association·2005·Department of Veterinary Pathobiology, United States·View original on PubMed →
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Original publication title: Adverse events diagnosed within three days of vaccine administration in dogs.
- Species:
- dog
Plain-English summary
A study found that some dogs can have adverse reactions shortly after getting vaccinated, with about 4,678 cases reported among over a million vaccinated dogs. Smaller, neutered dogs aged 1 to 3 years were more likely to experience these reactions, especially if they received multiple vaccines at once. Common symptoms included allergic reactions and other nonspecific vaccine reactions. If your dog is in this higher-risk group, it's important to monitor them closely for any unusual signs after vaccination and discuss any concerns with your veterinarian.
People also search for: dog vaccine side effects · why is my dog itching after vaccination · small dog vaccine reactions · neutered dog vaccine risks
Abstract
OBJECTIVE: To determine incidence rates and potential risk factors for vaccine-associated adverse events (VAAEs) diagnosed within 3 days of administration in dogs. DESIGN: Retrospective cohort study. ANIMALS: 1,226,159 dogs vaccinated at 360 veterinary hospitals. PROCEDURE: Electronic records from January 1, 2002, through December 31, 2003, were searched for possible VAAEs (nonspecific vaccine reaction, allergic reaction, urticaria, or anaphylaxis) diagnosed within 3 days of vaccine administration. Information included age, weight, sex, neuter status, and breed. Specific clinical signs and treatments were reviewed in a random sample of 400 affected dogs. The association between potential risk factors and a VAAE was estimated by use of multivariate logistic regression. RESULTS: 4,678 adverse events (38.2/10,000 dogs vaccinated) were associated with administration of 3,439,576 doses of vaccine to 1,226,159 dogs. The VAAE rate decreased significantly as body weight increased. Risk was 27% to 38% greater for neutered versus sexually intact dogs and 35% to 64% greater for dogs approximately 1 to 3 years old versus 2 to 9 months old. The risk of a VAAE significantly increased as the number of vaccine doses administered per office visit increased; each additional vaccine significantly increased risk of an adverse event by 27% in dogs < or = 10 kg (22 lb) and 12% in dogs > 10 kg. CONCLUSIONS AND CLINICAL RELEVANCE: Young adult small-breed neutered dogs that received multiple vaccines per office visit were at greatest risk of a VAAE within 72 hours after vaccination. These factors should be considered in risk assessment and risk communication with clients regarding vaccination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16220670/