Peer-reviewed veterinary case report
Dog food antibiotic residues linked to allergic reactions in dogs
By Di Cerbo, Alessandro et al.·Published in Veterinaria italiana·2018·Department of Medical, Italy·View original on PubMed →
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Original publication title: Adverse food reactions in dogs due to antibiotic residues in pet food: a preliminary study.
- Species:
- dog
Plain-English summary
Eight dogs with symptoms like ear infections, diarrhea, anxiety, and skin issues were fed an organic chicken-based diet for 15 days to see if it would help. After the diet, all the dogs showed significant improvement in their symptoms, and tests indicated a reduction in antibiotic residues in their blood. The study suggests that food contaminated with antibiotic residues might contribute to these food intolerances, but more research is needed to confirm this.
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Abstract
In the last decades, adverse food reactions have increased considerably in dogs and cats. In this study we report on the possible onset of food intolerances symptoms, including otitis, diarrhoea, generalised anxiety, and dermatitis in a cohort of 8 dogs consuming commercial diets. All dogs received an organic chicken-based diet for 15 days. We performed analysis of blood biochemical parameters, kibble composition, and oxytetracycline (OTC) serum concentration before and after 15 days of organic chicken-based diet supplementation. We hypothesised that a chronic intake of contaminated food enhanced by the presence of nanoparticle aggregates might be at the base of the onset of pharmacologic or idiopathic food intolerances. At the end of the evaluation period, an overall significant reduction of otitis, diarrhoea, generalised anxiety, and dermatitis was observed. Biochemical analyses indicate a significant increase in the alkaline phosphatase, from 41 to 52.5 U/L, after 15 days (••p <0.01), while a significant decrease in Gamma-glutamyl transferase and urea, from 9.37 to 6.25 U/L and from 32.13 ± 8.72 to 22.13 ± 7.8 mg/dL, respectively, was observed (•p <0.05). A significant decrease, from 0.22 to 0.02 μg/mL, in mean OTC serum concentration was also observed (••p <0.01). Composition analysis revealed the presence of OTC, calcium, aluminium, silicon, and phosphorous nanoparticle aggregates. Further research on a wider sample size would help to confirm the hypothesis proposed here.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29633230/