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Peer-reviewed veterinary case report

Adverse reactions to oral antibiotics in dogs and cats

By Kunkle, G A et al.·Published in Journal of the American Animal Hospital Association·1995·College of Veterinary Medicine, United States·View original on PubMed

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Original publication title: Adverse side effects of oral antibacterial therapy in dogs and cats: an epidemiologic study of pet owners' observations.

Species:
dog

Plain-English summary

This study looked at how dogs and cats reacted to oral antibiotics given to them at a university veterinary hospital over 18 months. Pet owners were asked about any negative side effects they noticed after their pets took these medications. Many owners reported problems specifically with erythromycin stearate, an antibiotic given to dogs, while trimethoprim-sulfadiazine, another antibiotic commonly used in dogs, did not seem to cause many issues. Overall, the study found that some antibiotics can lead to noticeable side effects in pets, particularly erythromycin stearate.

Abstract

This epidemiologic study surveyed pet owners for observations of adverse reactions to oral antibacterials which were prescribed to outpatients at a university teaching hospital. Multiple questions were asked of all clients whose dog or cat was treated during the 18-month study. The questionnaire was designed prospectively to define those reactions that clearly seemed to be medication related. In this study, owners noted a significant number of adverse side effects with erythromycin stearate administration to dogs. Trimethoprim-sulfadiazine was used most often in dogs but did not result in a substantial number of adverse reactions.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7820765/