Peer-reviewed veterinary case report
Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats.
- Journal:
- Pharmacology
- Year:
- 2004
- Authors:
- Singh, Vijay Pal et al.
- Affiliation:
- University Institute of Pharmaceutical Sciences · India
- Species:
- rodent
Abstract
The objective of the present study was to determine the effect of a selective cyclooxygenase-2 (COX-2) inhibitor in in-vivo dextran sodium sulfate (DSS)-stimulated distal colon tissues of the rat. Longitudinal colon tissue sections from DSS-treated rats exhibited noticeable inflammation, altered contraction, increased myleoperoxidase activity, and oxidative stress. When the animals were pretreated with celecoxib, a selective COX-2 inhibitor, the flare of the colon was further worsened in terms of all the parameters studied. There was a reduction in PGE2 levels on chronic administration of celecoxib in DSS-treated animals. The results of the present study suggest that COX-2 enzyme and prostaglandins derived from COX-2 might play a defensive role in protecting ulceration of the colon akin to that seen in the upper gastrointestinal tract.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15331912/