Peer-reviewed veterinary case report
Long-term control of grade II stage 2 mast cell tumors in dogs
By Lejeune, A et al.·Published in Veterinary and comparative oncology·2015·Davis William R. Pritchard Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012).
- Species:
- dog
Plain-English summary
A group of 21 dogs with grade II stage 2 mast cell tumors (a type of skin cancer) received a combination of local treatment, like surgery or radiation, along with chemotherapy drugs (prednisone, vinblastine, and CCNU). The dogs had a median survival time of about 1359 days, which is over three and a half years, and many lived disease-free for even longer. Those who had both surgery and radiation therapy before chemotherapy had the best outcomes. None of the dogs developed distant metastasis, meaning the cancer did not spread to other parts of the body.
People also search for: dog mast cell tumor treatment · canine cancer survival rates · chemotherapy for dog skin cancer
Abstract
This retrospective case series evaluates the outcome of 21 dogs with grade II stage 2 mast cell tumour (MCT) treated with adequate local therapy and adjuvant systemic chemotherapy (prednisone, vinblastine and CCNU). The median survival for all dogs was 1359 days (range, 188-2340). Median disease-free interval was 2120 days (149-2325 days). Dogs treated with surgery and chemotherapy had shorter survival (median, 1103 days; 188-2010 days) than those that underwent surgery, radiation therapy and chemotherapy as part of their treatment (median, 2056 days; 300-2340 days). Two patients had local recurrence in the radiation field and four patients had de novo MCT. Distant metastasis was not observed in any dogs. The results of this study suggest that, in the presence of loco-regional lymph node metastasis in grade II MCT, the use of prednisone, vinblastine and CCNU after adequate local-regional therapy can provide a median survival in excess of 40 months.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23721492/