Peer-reviewed veterinary case report
AKT capture by feline leukemia virus.
- Journal:
- Archives of virology
- Year:
- 2017
- Authors:
- Kawamura, Maki et al.
- Affiliation:
- The United Graduate School of Veterinary Science · Japan
- Species:
- cat
Abstract
Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called "oncogene capture". The captured cellular genes, referred to as "v-onc" genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", that has captured feline c-AKT1 in feline lymphoma. FeLV-AKT contains a gag-AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28005210/