Peer-reviewed veterinary case report
Alcohol-triggered signs of migraine: An animal model.
- Journal:
- Somatosensory & motor research
- Year:
- 2016
- Authors:
- Alabwah, Yaqoub et al.
- Affiliation:
- a Department of Endodontics · United States
- Species:
- rodent
Abstract
We describe an animal model where characteristics of migraine can be triggered by alcohol administration. In rats chronically implanted with a cannula overlying the transverse sinus, we applied potassium chloride (KCl) (or saline) to the meninges to sensitize trigeminovascular afferents. We assessed effects of repeated KCl application on animal behavior using conditioned place avoidance paradigm. In KCl-treated rats we discovered that alcohol injections (0.2 mg/kg), but not saline, resulted in the development of extracephalic allodynia and signs of ongoing pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27021138/