Peer-reviewed veterinary case report
Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model.
- Journal:
- Advances in experimental medicine and biology
- Year:
- 2018
- Authors:
- Szabo, Gyongyi
- Affiliation:
- Department of Medicine · United States
Abstract
HCC is a rapidly increasing cancer worldwide. Most HCC rises in the setting of chronic and advanced liver disease caused by viral hepatitis, alcohol use, non-alcoholic liver disease or their combination. We found that in the mouse model, alcohol alone does not induce HCC, however, it can promote HCC development after a carcinogen exposure. Multiple mechanisms are involved in carcinogenesis and alcohol affects many of those including epithelial-mesenchymal transition, cancer stem marker expression and inflammation as evidenced in our HCC model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30362091/