Peer-reviewed veterinary case report
Alkaloids from roots of Stemona sessilifolia and their antitussive activities.
- Journal:
- Planta medica
- Year:
- 2009
- Authors:
- Yang, Xin-Zhou et al.
- Affiliation:
- Shanghai Institute of Materia Medica · China
- Species:
- rodent
Abstract
Protostemonamide ( 1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine ( 2), stemospironine ( 4), and maistemonine ( 7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine ( 11) had antitussive activity following i. c. v. administration.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19031364/