Peer-reviewed veterinary case report
Alkylsulfanyl analogs as potent αδ ligands.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2018
- Authors:
- Shimada, Kousei et al.
- Affiliation:
- R&D Division · Japan
Abstract
We identified novel (3R, 5S)-3-aminomethyl-5-methanesulfanyl hexanoic acid (5a: DS75091588) and (3R, 5S)-3-aminomethyl-5-ethanesulfanyl hexanoic acid (6a: DS18430756) as sulfur-containing γ-amino acid derivatives that were useful for the treatment of neuropathic pain. These two compounds exhibited a potent analgesic effect in animal models of both type I diabetes and type II diabetes, and good pharmacokinetics.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29752183/