Alleviates Colitis via the IL-22/Occludin Signal Pathway.

Abstract

Ulcerative colitis (UC) is the most common inflammatory bowel disease, and its incidence has increased in recent years. Recent clinical and experimental data indicate that gut microbiota plays a pivotal role in the pathogenesis of UC.establishes a stable and persistent colonization in the gastrointestinal tract without apparent pathogenicity to gastrointestinal or extragastrointestinal tissues. However, the detailed effects ofon the gastrointestinal tissue remain unknown. The primary aim of this study is to investigate the effects of() on development of colitis induced by dextran sodium sulfate (DSS) and the underlying molecular mechanism. The results suggested thatsignificantly improved colitis symptoms-including weight loss, disease activity index, colon length, and histopathological changes in the colon caused by DSS-and alleviated the reduced expression of interleukin-22 and occludin in the colonic tissue due to DSS administration. Furthermore, the absence of IL-22 completely preventedfrom alleviating colitis and significantly decreased the levels of occludin, an important downstream effector protein of IL-22. These findings suggest thatameliorates ulcerative colitis induced by DSS via the IL-22/occludin signal pathway.