alleviates sleep deprivation-induced intestinal barrier dysfunction and neuroinflammation in mice.

Abstract

Consuming probiotic products is a solution that people are willing to choose to augment health. As a global health hazard, sleep deprivation (SD) can cause both physical and mental diseases. The present study investigated the protective effects of(), a widely used probiotic, on a SD mouse model. Here, it has been shown that SD induced intestinal damage in mice, whilesupplementation attenuated disruption of the intestinal barrier and enhanced the antioxidant capacity. Microbiome analysis revealed that SD caused dysbiosis in the gut microbiota, characterized by increased levels of,, and, as well as decreased levels of, which were partially ameliorated by. Moreover, SD resulted in elevated pro-inflammatory cytokine concentrations in both the intestine and the brain, whileprovided protection in both organs.supplementation significantly improved locomotor activity in SD mice. Although heat-killedshowed some protective effects in SD mice, its overall efficacy was inferior to that of live. In terms of mechanism, it was found that AG1478, an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, could diminish the protective effects of. In conclusion,demonstrated the ability to alleviate SD-induced intestinal barrier dysfunction through EGFR activation and alleviate neuroinflammation.