Peer-reviewed veterinary case report
Hair loss linked to high urinary corticoids in Pomeranians
By Cerundolo, R et al.·Published in The Veterinary record·2007·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback.
- Species:
- dog
Plain-English summary
A group of Pomeranians and miniature poodles with hair loss (alopecia) were tested for hormone levels in their urine. The tests showed that these dogs had higher levels of certain hormones compared to healthy dogs, indicating possible adrenal gland issues. When given a low dose of dexamethasone, a medication that helps regulate hormone levels, many of the alopecic dogs did not respond as expected, suggesting they were resistant to the treatment. However, when a higher dose of dexamethasone was given, their hormone levels dropped to normal. This suggests that adjusting the treatment could help manage their condition better.
People also search for: Pomeranian hair loss treatment · miniature poodle alopecia causes · dog hormone imbalance symptoms
Abstract
The adrenocortical function of pomeranians and miniature poodles with alopecia was tested by serial measurements of the urinary corticoid:creatinine ratio (uccr) and by an oral low-dose dexamethasone suppression test (lddst) and uccr measurements. In most of the dogs there was day-to-day variation in the uccrs of the 10 sequential urine samples, often with values above or below the upper limit of the range of healthy control dogs. In 22 alopecic pomeranians the basal uccrs were significantly higher than in 18 non-alopecic pomeranians, and the values of both groups were significantly higher than those of 88 healthy pet dogs. The uccrs of 12 alopecic miniature poodles were significantly higher than those of healthy dogs. In 12 alopecic pomeranians and eight alopecic miniature poodles the oral lddst revealed increased resistance to dexamethasone. In six non-alopecic pomeranians the uccrs after the administration of dexamethasone were not significantly different from those in seven healthy dogs at the same time. In an oral high-dose dexamethasone suppression test, using 0.1 mg dexamethasone/kg bodyweight, the uccrs of seven alopecic pomeranians and five alopecic miniature poodles decreased to low levels.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17384290/