Peer-reviewed veterinary case report
Changes in skin ceramides in dogs with atopic dermatitis
By Yoon, Ji‐Seon et al.·Published in Experimental Dermatology·2011·View original on Crossref →
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Original publication title: Alteration of stratum corneum ceramide profiles in spontaneous canine model of atopic dermatitis
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) showed changes in the levels of certain fats called ceramides in their skin. These ceramides are important for keeping the skin barrier healthy. Researchers found that dogs with this condition had lower amounts of specific ceramides compared to healthy dogs. This study suggests that dogs with atopic dermatitis can help us understand similar skin issues in humans, as they share similar ceramide profiles.
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Abstract
Abstract: Ceramides (CERs) in the stratum corneum (SC) are thought to play a key role in cutaneous barrier function. It has been reported that human SC contains 11 free CER classes and that their profiles are altered in humans with atopic dermatitis (AD). Although decreased proportions of free CERs or quantities of protein‐bound CERs in the SC have been reported in dogs with AD, the overall profile of CERs in the canine SC has not been fully elucidated. The aim of this study was thus to investigate the profile of free CERs in the canine SC and to identify alterations in the CER profiles in dogs with AD. Normal‐phase liquid chromatography–electrospray ionization–mass spectrometry indicated 11 clusters of peaks for free CER classes, similar to those recognized in the human SC. The fractions of free SC CER in dogs with AD and in breed‐ and age‐matched healthy dogs were quantitatively compared using high‐performance thin‐layer chromatography. CER[EOS], CER[EOP] and CER[NP], which are known to be decreased in the skin of humans with AD, were also decreased in the skin of dogs with AD. These findings highlight canine AD as a spontaneous animal model for investigating the disruption of CER‐associated cutaneous barrier functions in the corresponding human disease.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1600-0625.2011.01306.x