Peer-reviewed veterinary case report
Changes in skin protein genes in dogs with atopic dermatitis
By Theerawatanasirikul, Sirin et al.·Published in Research in veterinary science·2012·Department of Veterinary Pathology·View original on PubMed →
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Original publication title: Alterations of keratins, involucrin and filaggrin gene expression in canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A dog with atopic dermatitis (CAD), a common allergic skin condition, may show symptoms like itching, redness, and skin lesions. Researchers found that certain proteins in the skin, which help protect and repair it, were produced in higher amounts in dogs with this condition. Specifically, proteins called keratins, involucrin, and filaggrin were more active in the affected skin. This study highlights the connection between these proteins and the skin issues seen in dogs with CAD, which could help in developing better treatments in the future.
People also search for: dog itchy skin treatment · atopic dermatitis in dogs · dog skin allergy symptoms
Abstract
Canine atopic dermatitis (CAD) is a common allergic skin disease in dogs, associated with a defective epidermal barrier. In this study we investigated the alterations in skin keratinocyte proliferation and differentiation in CAD by quantitative reverse transcription-polymerase chain reaction. Gene expression of keratin (KRT) markers of proliferative and differentiated keratinocytes, together with that of cornified envelope proteins, involucrin (IVL) and filaggrin (FLG), were evaluated. An upregulation of KRT5 and KRT17 in both lesional and non-lesional AD skin was observed (p<0.05) whereas KRT2e, KRT14, IVL and FLG expression were significantly increased only in lesional AD skin (p<0.05). Additionally, the expression levels of KRT5, KRT14, KRT17 and IVL in CAD were strongly correlated. In conclusion, the expression of the majority of the studied keratins, as well as IVL and FLG is increased in CAD with close correlation between the proliferative keratins. This is the first report of a correlation of KRT and IVL genes with CAD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22784629/